Clotilde Théry

Clotilde Théry
Paris (FRA)


After working on early steps of brain development during post-doc positions in Oxford University (UK) and Columbia (USA), Clotilde Théry returned to Paris where she initially did her PhD in Developmental Biology. By joining the lab of S. Amigorena in 1996 at Institute Curie, her major scientific interest became the study of small vesicles, called exosomes. Exosomes have been implicated in intercellular communication between immune and tumor cells. From 1998 until 2007, C. Théry focused on exosomes secreted by dendritic cells (DC’s) and revealed that DC-derived exosomes harbor antigen and MHC-peptide complexes which can be ingested by other DCs in order to activate antigen-specific T cells and thus boost the immune response. Also the investigation of physiological functions and possible modulation of exosome, and also of other extracellular vesicle (EV) secretion, both during tumor growth and an in vivo response, became core aims in more recent research.

During her scientific career Clotilde Théry published more than 90 articles in international peer-reviewed journals and is a regular invitee to international conferences. In addition, she organized an international Workshop on Exosomes in Paris (2011), after which was decided the creation of the International Society of Extracellular Vesicles (ISEV). She functioned as vice-President (2011) as well as Secretary General (2012-2016) for ISEV, and as co-editor in chief of its journal, Journal of Extracellualr vesicles (since 2012). Clotilde Théry’s dedication to her work shall not only serve to create novel vaccines from modified tumor or immune extracellular vesicles but also to establish an international scientific society network about the biology of extracellular vesicles.

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